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Impaired signal transmission in women with preeclampsia reduces blood flow.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Impaired signal transmission in women with preeclampsia reduces blood flow.
According to a study from England, "there is evidence that tissue blood flow is regulated by retrograde transmission of signals initiated at capillary and post-capillary sites, and transmitted via the endothelium to modulate pre-capillary resistance. We have used preeclampsia as a model to test the hypothesis that normal endothelium is required to enable adjustment of blood flow to match tissue requirements. Integrity of the endothelial pathway was assessed by measuring calf blood flow at increasing venous pressures, using an established small cumulative-step venous-congestion plethysmography protocol in ten women with preeclampsia, 17 normal pregnant controls and ten non-pregnant women."
"Endothelial cell activation was assessed by measuring plasma levels of the cell adhesion molecules, intercellular cell-adhesion molecule-I (ICAM-I), vascular cell-adhesion molecule-I (VCAM-I) and E-selectin. Baseline calf blood flow was significantly lower in preeclampsia than in the other two groups (p
"In the preeclampsia group, there was a fall in blood flow as venous congestion pressure was raised (p
"The differences between the preeclamptic women and the other two groups support the notion that the failure to sustain blood flow during a cumulative pressure step protocol in the preeclamptic group might be ...
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- Impaired signal transmission in women with preeclampsia reduces blood flow.
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Source: HighBeam Research, Impaired signal transmission in women with preeclampsia reduces blood...