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Soy isoflavone aglycones have estrogenic effects on mouse reproductive tracts.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Isoflavone aglycones have estrogenic effects on mouse reproductive tracts.
According to researchers in the United States, "we assessed the effects of dietary consumption of soy isoflavone aglycones on the reproductive tract of sexually mature male and female mice. Isoflavone concentrates with a ratio of 10:1, 2:1 or 1:10 genistein:daidzein (G:D) were added to provide 120 mg total isoflavones/1800 calories (approximately 40 mg/kg body weight) to diets having either casein/lactalbumin or soy protein isolate as the source of protein. After 16 weeks, mice were necropsied and gross and histopathologic assessments of uterus, vagina, testes and accessory sex glands were completed."
"Effects of the 10G:1D isoflavone concentrates were absent or minimal in females but in males included atrophy of accessory sex glands. In contrast, the 2G:1D and 1G:10D concentrates caused dramatic estrogenic effects in both male and female mice," said J.M. Cline and colleagues, Wake Forest University, School of Medicine.
"Effects in females included endometritis and effects typical of estrogenic stimulation (i.e., uterine enlargement, keratinization of vaginal epithelium, increased height of endometrial surface epithelial cells, and uterine squamous metaplasia). ...
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Source: HighBeam Research, Soy isoflavone aglycones have estrogenic effects on mouse...