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In situ hybridization techniques may be able to detect HPV.

Women's Health Weekly

| March 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAR 4 - (NewsRx.com & NewsRx.net) -- High-risk human papillomaviruses (HPVs) might be detected by sensitive in situ hybridization techniques.

"Human papillomaviruses are accepted as a necessary cause of cervical neoplasia. However, the benefits of testing simply for high-risk HPV types are limited because of their high prevalence in intraepithelial lesions of all grades, the majority of which regress if left untreated," scientists in the United States report.

"One factor considered to be of key importance for the progression of intraepithelial lesions to invasive disease is integration of HPV into the host cell genome. Although questions remain about the prevalence of integration amongst pre-invasive lesions, sensitive in situ hybridization techniques utilizing tyramide reagents may aid determination of the significance of HPV infection by enabling routine detection of both high-risk HPV and its physical status," wrote M.F. Evans and colleagues, University of Vermont, ...

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