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HPV, chromosome aberrations correlate with transition to microinvasive carcinoma.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Integration of human papillomavirus (HPV) 16/18 DNA is an important event in the transition of cervical intraepithelial neoplasia (CIN I, II, and III) to microinvasive carcinoma.
"Cervical intraepithelial neoplasia I, II, and III and cases of CIN III associated with microinvasive cervical carcinoma (III & mCA) were analyzed for evidence of episomal or integrated HPV 16/18 DNA by fluorescence in situ hybridization (FISH)," scientists in Netherlands report.
"In parallel, numerical aberrations of chromosomes 1, 17, and X were determined in these lesions as indicators of genomic instability. HPV 16/18 DNA was present in 2 of 12 CIN I, 19 of 23 CIN II/III, and 10 of 12 CIN III & mCA," wrote A.H.N. Hopman and colleagues, University of Maastricht, Department of Molecular Cell Biology.
"None of the CIN I and only 2 of the 19 HPV 16/18-positive solitary CIN II/III showed an integrated HPV pattern. However, all 10 cases of HPV-positive CIN III & mCA showed this pattern. Transition of CIN II/III to CIN III & mCA therefore correlates strongly with viral integration (p
Chromosomal aberrations were detected in 23 of 31 HPV 16/18-positive lesions (14 solitary CIN I-III and 9 CIN III & mCA) and 5 of 16 HPV-negative lesions. Nine of 21 HPV 16/18-positive solitary CIN I-III showed tetrasomy for all chromosomes tested, while trisomies for a single chromosome were seen in a further 5 of these HPV-positive lesions," the researchers stated.
"In 8 of 10 ...
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