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ER packaging chaperone determines virulence of Candida albicans.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans.
"The Candida albicans CSH3 gene encodes a functional and structural homologue of Shr3p, a yeast protein that is specifically required for proper uptake and sensing of extracellular amino acids in Saccharomyces cerevisiae. A Candida csh3Delta/csh3Delta null mutant has a reduced capacity to take up amino acids, and is unable to switch morphologies on solid and in liquid media in response to inducing amino acids," researchers in Sweden report.
"CSH3/csh3Delta heterozygous strains display normal amino acid induced morphological switching," stated Paula Martinez and Per O. Ljungdahl at the Ludwig Institute for Cancer Research in Stockholm. "However, although heterozygous cells apparently sense and properly react to amino acid induced signals they cannot take up amino acids at wild-type rates.
"Strikingly, both CSH3/csh3Delta heterozygous and csh3Delta/csh3Delta homozygous strains are unable to efficiently mount virulent infections in a mouse model. The haploinsufficiency ...
- ER packaging chaperone determines virulence of Candida albicans.
- Newspaper article from: Biotech Week March 3, 2004 700+ words
...determines the amino acid uptake capacity and virulence of Candida albicans. "The Candida...high-capacity amino acid uptake in wild...determines the amino acid uptake capacity and virulence of Candida albicans. Mol Microbiol...
- Scientists Develop 'Super Peptide' That Kills Candida Albicans - Fungus...
- Press release article from: PR Newswire February 20, 2003 700+ words
...developed a 'super' peptide that kills Candida albicans (C. albicans), a single-celled...team chose to focus on the alpha-MSH amino acid sequence (6-13), which contains...substitutions in the alpha-MSH (6-13) amino acid sequence can either enhance or reduce...
- Scientists develop 'Super Peptide' that kills Candida albicans - Fungus...
- Press release article from: PR Newswire February 20, 2003 700+ words
...developed a 'super' peptide that kills Candida albicans (C. albicans), a single-celled...team chose to focus on the alpha-MSH amino acid sequence (6-13), which contains...substitutions in the alpha-MSH (6-13) amino acid sequence can either enhance or reduce...
- Farnesol restores wild-type colony morphology to 96% of Candida albicans colony...
- Magazine article from: Genome Jensen, Ellen C. Hornby, Jacob M. Pagliaccetti, Nicole E. Wolter, Chuleeon M. Nickerson, Kenneth W. Atkin, Audrey L. April 1, 2006 700+ words
Abstract: Candida albicans is a diploid fungus that undergoes...regulated in part by quorum sensing. Candida albicans produces and secretes farnesol...synthesis mutants, quorum sensing, Candida albicans, morphological transition...
- The reduction of Candida albicans "yeast" overgrowth using Fungal Defense and...
- Magazine article from: Townsend Letter for Doctors and Patients Goldberg, Paul A. November 1, 2003 700+ words
Candida albicans, a member of the yeast family...factor in numerous health problems. Candida albicans is a normal inhabitant of the gastrointestinal...pathogenic bacteria. The nature of Candida albicans, however, is that it is an opportunistic...
- In-vitro adherence of candida albicans to conjunctival epithelial cells of...
- Magazine article from: Indian Journal of Ophthalmology Bhardwaj, Gabu Vashist, Shashi Khan, Imtiaz July 1, 1985 700+ words
...infections' and perhaps in case of Candida albicans too, as in mucocutaneous Candidia...sup] 5 cells/ml of PBS. Yeasts : Candida albicans, a clinical iso-late was grown...cases showed enhanced adherence of Candida albicans to conjunctival epithelial cells but...
- Inhibitory effect of ginger extract on Candida albicans.(Report)
- Magazine article from: American Journal of Applied Sciences Atai, Zahra Atapour, Manijeh Mohseni, Maryam June 1, 2009 700+ words
...zingiber officinale" on Candida albicans was investigated. MATERIALS...fungi used in this study, Candida albicans (PTCC 5027 and ATCC 10231...collection (Tehran, Iran). Candida albicans was cultured and maintained...
- Low virulent strains of Candida albicans aid quest for vaccine.
- Newspaper article from: Drug Week December 31, 2004 700+ words
...net) -- Low virulent strains of Candida albicans aid in the quest for a vaccine against...candidiasis. "Several low virulent Candida albicans mutant strains: CM1613 (deleted...Proteomics (Low virulent strains of Candida albicans: Unraveling the antigens for a future...
