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TNP-470 blocks carcinosarcoma-induced tube formation.

Women's Health Weekly

| March 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAR 4 - (NewsRx.com & NewsRx.net) -- TNP-470 blocks carcinosarcoma-induced tube formation.

According to researchers in Japan, "we evaluated the usefulness of TNP-470 as an anticancer agent on a human uterine carcinosarcoma cell line (FU-MMT-1). FU-MMT-1 induced human arterial endothelial cell (HAEC) tube formation on an in vitro cocultured model of FU-MMT-1 and HAECs on a matrix gel, and was blocked by vascular endothelial growth factor (VEGF)-2 receptor (KDR/Flk-1) tyrosine inhibitor. Lower concentration of TNP-470 inhibited the tube formation."

"Cell proliferation of FU-MMT-1 but not HAEC was inhibited by lower concentration of TNP-470. In addition, lower concentration of TNP-470 blocked VEGF production on FU-MMT-1," wrote S. Miura and colleagues, Fukuoka University, School of Medicine.

"Our results suggest that TNP-470 directly inhibited FU-MMT-1 but not HAEC growth accompanied with the ...

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Source: HighBeam Research, TNP-470 blocks carcinosarcoma-induced tube formation.