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Paget carcinoma cells differ from those of the underlying carcinoma.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Study finds that the underlying tumors in the breast are coincidental neoplastic lesions (collision tumors) different from Paget carcinoma (PC) cells.
"Paget's carcinoma of the breast is characterized by neoplastic cells of ''glandular'' type located within the epidermis of the nipple-areolar complex, often associated with an underlying ductal carcinoma, either in situ or invasive. At present the origin of PC cells is controversial, although there is a widespread opinion that PC cells are ''foreign'' elements to the epidermis resulting from an epidermotropic migration of neoplastic elements from an underlying ductal carcinoma," scientists writing in the journal Human Pathology report.
"An alternative view is that some cases result from neoplastic transformation of preexisting, innocent intraepidermal clear cells of the nipple-areolar complex (Toker cells) that migrate from nonneoplastic ducts," wrote L. Morandi and colleagues, University of Bologna, Osped Bellaria.
"Consequently, 10 cases were studied using methods for clonality (i.e., loss of heterozygosity and mitochondrial DNA displacement loop sequence analysis). Microdissection of intraepidermal neoplastic cells and of cells from underlying duct carcinomas and metastases was performed," the ...
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Source: HighBeam Research, Paget carcinoma cells differ from those of the underlying carcinoma.