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Mutations, especially 11q loss, may be involved in early-onset breast tumors.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- The combined use of genomic patterns and molecular targets may provide a useful tool for diagnostic, therapeutic, and prognostic purposes in early-onset breast tumor development in Taiwanese women.
"Nearly 30% of the breast cancer patients in the Taiwanese community have their diseases diagnosed before the age of 40. Their 5-year survival rate is poorer than that of their late-onset breast cancer counterparts. Genomic abnormalities between these two breast cancer age groups were compared using comparative genomic hybridization (CGH) analyses," scientists in Taiwan report.
"The sample set was made up of 44 early-onset ( <35 years old) and 54 late-onset cases (>63 years old). Frequent CGH changes were noted, such as gains on 8q, 1q, and 17q and losses on 16q, 17p, and 8p. These were very similar for the two age groups, as well as for Taiwanese women and other ethnic populations," wrote Y.J. Jong and colleagues, National Yang Ming University, Institute Genetics.
"In contrast, several less common lesions, such as gains on 16p and 8p and losses on 11q and 9p, were significantly different between the early- and late-onset breast tumors. In addition, more profound chromosomal changes were consistently associated with the more advanced-stage tumors, and less expression of the estrogen and the progesterone receptors, and of HER-2/neu," the researchers wrote.
"About 19% of the breast cancers examined carried a TP53 mutation ...
- Mutations, especially 11q loss, may be involved in early-onset breast tumors.
- Newspaper article from: Cancer Weekly March 2, 2004 700+ words
...purposes in early-onset breast tumor development...early- and late-onset breast tumors. In addition...a role in early-onset breast tumor formation...published their study in Cancer Genetics and Cytogenetics...
- Study data from University Hospital update knowledge of breast cancer...
- Newspaper article from: Cancer Weekly November 17, 2009 700+ words
...mutations to early-onset breast cancer in French...also Breast Cancer Genetics). "The frequencies...with early-onset breast cancer. It...mutations to early-onset breast cancer in French...Montreal, Breast Cancer Genetics, BRCA1, BRCA2...
- Research from National Center for Scientific Research yields new findings on...
- Newspaper article from: Cancer Weekly July 14, 2009 700+ words
...Cancer report (see also Breast Cancer Genetics). "Previous studies in Greek...Among 140 patients with early-onset breast cancer (<40 years), 14...Keywords: Greece, Athens, Breast Cancer Genetics, Breast Cancer, Breast Carcinoma...
- New data from Fudan University, Breast Cancer Institute illuminate research in...
- Newspaper article from: Cancer Weekly June 30, 2009 700+ words
...Republic of China report (see also Breast Cancer Genetics). "In the first hospital-based...population set (familial/early-onset breast cancer cases and community-based...Republic of China, Shanghai, Breast Cancer Genetics, Breast Cancer, Breast Carcinoma...
- Studies from Allegheny General Hospital, Department of Human Oncology yield new...
- Newspaper article from: Cancer Weekly November 17, 2009 700+ words
...mutation (5301insA) who developed early onset breast cancer with no strong family history...United States report (see also Breast Cancer Genetics). "Subsequent site-specific analysis...United States, Pittsburgh, Breast Cancer Genetics, BRCA2, Breast Cancer, Breast Carcinoma...
- Study confirms value of family-history knowledge for young women.(breast cancer...
- Magazine article from: Women's Health Weekly April 17, 2003 700+ words
...and the ovaries" (Lalloo F, Varley J, Ellis D, et al., Prediction of pathogenic mutations in patients with early-onset breast cancer by family history. Lancet, 2003;361(9363):1101). This article was prepared by Women's Health Weekly editors...
- BRCA1 and BRCA2 mutations may contribute to early-onset breast cancer in...
- Newspaper article from: Health & Medicine Week August 4, 2003 700+ words
...mutations may contribute to early-onset breast cancer in Germany. "This study was...may contribute similarly to early-onset breast cancer in Germany. Given current constraints...BRCA2 germline mutations to early-onset breast cancer in Germany. Eur J Human Genet...
- Researchers study familial and early onset breast cancer in African Americans.
- Newspaper article from: Medical Devices & Surgical Technology Week February 8, 2004 700+ words
2004 FEB 8 - (NewsRx.com & NewsRx.net) -- In order to identify the spectrum of BRCA2 mutations in African Americans, researchers investigated breast or ovarian cancer patients from 74 independent families at elevated risk of germline mutations. According to recent research from the United
