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Free estradiol and breast cancer risk can be calculated for use in studies.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Study results suggest that for epidemiological studies, it is only necessary to measure total estradiol (E2) concentration and sex hormone binding globulin (SHBG) concentration, with hormone fractions being obtained by calculation, producing savings in cost, time, and serum.
"Mathematical methods exist to determine the fractions of sex hormones bound to albumin, bound to (SHBG), or unbound, using total hormone concentration and SHBG concentration," scientists in England report.
"We used data from eight prospective studies of postmenopausal women to assess the validity of these estimates for fractions of (E2) and to investigate the impact of using calculated values in breast cancer relative risk (RR) models. Comparisons were made between measured and calculated concentrations of free and non-SHBG-bound E2 in four studies," wrote T.J. Key and colleagues, Oxford University, Radcliffe Infirmary.
"Relationships between the hormone fractions were investigated and a sensitivity analysis of the calculation performed. Breast cancer RRs were estimated using conditional logistic regression by quintiles of free E2. There is a high correlation (r > 0.91) between calculated and measured values of both free and non-SHBG-bound E2," the researchers wrote.
"The calculation is highly sensitive to total hormone concentration but is relatively insensitive to SHBG concentration. In studies ...
- Free estradiol and breast cancer risk can be calculated for use in studies.
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