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A new assay detects MGB1 transcript in the blood of breast cancer patients.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers develop a sensitive assay to detect mammaglobin (MGBI)in peripheral blood of breast cancer patients, which may have prognostic significance.
According to researchers writing in the International Journal of Cancer, "We describe a new one-step RT-PCR assay for the detection of the in MGBI gene transcript in the peripheral blood of breast cancer patients. With this approach, the MGBI transcript could be detected in the peripheral blood of 22 of 54 (41%) breast cancer patients prior to any therapy."
"This method, using specific primers for cDNA synthesis, proved to be more sensitive (10[superscript]-6 to 10[superscript]-11, usually 10[superscript]-7) than previously reported methodologies. This increased sensitivity was achieved without compromising specificity, as the MGBI transcript was not detected in 38 blood samples of healthy donors and in only 1 of 18 blood samples of patients presenting with hematologic malignancies," wrote N. Cerveira and colleagues, Portuguese Oncology Institute, Department of Genetics.
"A positive correlation was seen between MGBI positivity and breast cancer stage: 0/3 (0%) in stage 0, 3/13 (23%) in stage I, 6/17 (35%) in stage II, ...
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