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Epidemiology of otitis media caused by S. pneumoniae reported.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Scientists report the epidemiology of acute otitis media caused by Streptococcus pneumoniae before and after licensure of the 7-valent pneumococcal protein conjugate vaccine.
"We studied, by pulsed-field gel electrophoresis, multilocus sequence typing and penicillin-binding protein 2b amplicon-restriction profiles, pneumococcal isolates recovered from children with acute otitis media during 1 January-31 December 1999 and 2001. The proportion of nonvaccine serogroups increased from 14.8% (13/88) to 36.5% (23/63) from 1999 to 2001 (p
"Among children who received at least two doses of the pneumococcal 7-valent protein conjugate (PNC7) vaccine, 46.7% (7/15) of the isolates had nonvaccine serogroups, compared with 20.8% (26/125) of the isolates from children who did not receive the PNC7 vaccine (p=0.05)," stated M. Catherine McEllistrem and collaborators at the University of Pittsburgh, Baylor College of Medicine, and Texas Children's Hospital. "Overall, the serogroups involved in capsular switching were 6-19-NT, 6-14-35, 15-19, and the 19-Spanish 23F clone. In 1999 and 2001, 30.8% (4/13) and 26.1% (6/23) of the nonvaccine serogroups were implicated in capsular switching, respectively."
The researchers ...
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Source: HighBeam Research, Epidemiology of otitis media caused by S. pneumoniae reported.