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Conjugate vaccines may prevent otitis media.

Vaccine Weekly

| March 03, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Conjugate vaccines may be able to prevent otitis media.

According to a study from England, "The relative abilities of pneumococcal serotypes and strains (clones) to cause acute otitis media (AOM) were investigated by comparing the serotypes and genotypes of pneumococci recovered from cases of AOM (n=149) in children

"Comparing individual serotypes, 19F and 23F had 2- to 2.5-fold higher ORs, although these were not markedly different from the ORs of nonvaccine serotypes," reported William P. Hanage at Imperial College London and collaborators in England and Finland. "None of the major clones had an OR that was significantly greater than the average, and the differences in ORs among serotypes and clones were much less than those for invasive disease, suggesting little variation in their ability to cause AOM. We conclude that serotype replacement may reduce the long-term efficacy of these vaccines against acute otitis media."

Hanage and his coauthors published the results of their research in Infection and Immunity (Ability of pneumococcal serotypes and clones to cause acute otitis media: ...

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