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Apical membrane antigen 1 mediates merozoite attachment to host cells.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells.
"Apical membrane antigen 1 (AMA-1) of Plasmodium merozoites is established as a candidate molecule for inclusion in a human malaria vaccine and is strongly conserved in the genus. We have investigated its function in merozoite invasion by incubating Plasmodium knowlesi merozoites with red cells in the presence of a previously described rat monoclonal antibody (MAb R31C2) raised against an invasion-inhibitory epitope of P. knowlesi AMA-1 and then fixing the material for ultrastructural analysis," scientists in England report.
"We have found that the random, initial, long-range (12 nm) contact between merozoites and red cells occurs normally in the presence of the antibody, showing that AMA-1 plays no part in this stage of attachment," stated Graham H. Mitchell and colleagues at Guy's, King's, and St. Thomas' School of Medicine. "Instead, inhibited merozoites fail to reorientate, so they do not bring their apices to bear on the red cell surface and do not make close junctional apical contact.
...- Recombinant Plasmodium apical membrane antigen 1 confers protection.
- Newspaper article from: Biotech Week January 22, 2003 700+ words
...challenge facing malaria vaccine development...candidate. Apical membrane antigen 1 (AMA1) has...for an asexual malaria vaccine, but without...subject areas of Malaria, Vaccine Development, Apical Membrane Antigen 1, Animal Models...
- Recombinant Plasmodium apical membrane antigen 1 confers protection.(Brief...
- Newspaper article from: Vaccine Weekly January 22, 2003 700+ words
...challenge facing malaria vaccine development...candidate. Apical membrane antigen 1 (AMA1) has...for an asexual malaria vaccine, but without...subject areas of Malaria, Vaccine Development, Apical Membrane Antigen 1, Animal Models...
- Apical membrane antigen 1 mediates merozoite attachment to host cells.
- Newspaper article from: Drug Week March 5, 2004 700+ words
...net) -- Apical membrane antigen 1, a major malaria vaccine candidate, mediates...cells. "Apical membrane antigen 1 (AMA-1) of...Immunity (Apical membrane antigen 1, a major malaria vaccine candidate, mediates...
- Apical membrane antigen 1 protects monkeys against malaria.
- Newspaper article from: Malaria Weekly (Atlanta, GA) February 3, 2003 700+ words
...falciparum apical membrane antigen 1 (AMA1) were...challenge facing malaria vaccine development programs...candidate. Apical membrane antigen 1 has been identified...for an asexual malaria vaccine, but without...search term "malaria vaccine" yielded ...
- GenVec Announces Additional Funding for Malaria Vaccine Program from the PATH...
- Press release article from: Business Wire May 1, 2007 700+ words
...Agreement with the PATH Malaria Vaccine Initiative (MVI...new multivalent malaria vaccine towards clinical...MSP1) and apical membrane antigen-1 (AMA1), are...for an effective malaria vaccine." About Malaria...
- A Step Closer to a Malaria Vaccine.
- News wire article from: AScribe Science News Service August 29, 2005 700+ words
...structure of a promising malaria-vaccine component. This...fully protective malaria vaccine will likely consist...known as "Apical Membrane Antigen 1" (AMA1), a...in developing a malaria vaccine, see http...
- Bioject Signs CRADA with US Navy to Study a Malaria Vaccine.
- Press release article from: Business Wire May 5, 2009 700+ words
...technology for a malaria vaccine the Navy is developing...Protein and Apical Membrane Antigen 1 in Malaria-Naove...the US Military Malaria Vaccine Program's first...delivery device for a malaria vaccine in Phase I human...
- Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an...
- Magazine article from: Archives of Pathology & Laboratory Medicine Abbadi, Mousa A. Al- Almasri, Nidal M. Quran, Samer Al- Wilkinson, Edward J. February 1, 2007 700+ words
...expression of cytokeratin and epithelial membrane antigen in angiosarcoma. Design.--To...2 and AE1/AE3) and epithelial membrane antigen using standard immunohistochemical...had enough material for epithelial membrane antigen staining. Results.--In the 33...
