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IL-23 induces strong immune responses in hepatitis C DNA immunization.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- IL-23 induces stronger sustained CTL and Th1 immune responses than does IL-12 after hepatitis C virus envelope protein 2 DNA immunization.
"IL-23 is a heterodimeric cytokine consisting of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess IL-12-like biological activities, but is different in its capacity to stimulate memory T cells in vitro. In this study, we investigated whether IL-23 could influence envelope protein 2 (E2)-specific cell-mediated immunity induced by immunization of hepatitis C virus E2 DNA," investigators in South Korea report.
"We found that IL-23 induced long-lasting Th1 and CTL immune responses to E2, which are much stronger than IL-12-mediated immune responses," said Sang-Jun Ha and collaborators at Pohang University of Science and Technology and Ewha Woman's University. "Interestingly, IL-23N220L, an N-glycosylation mutant showing reduced expression of excess p40 without changing the level of IL-23, exhibited a higher ratio of IFN-gamma- to IL-4-producing CD4+ T cell frequency than did wild-type IL-23, suggesting a negative regulatory effect of p40 on Th1-prone immune response ...
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Source: HighBeam Research, IL-23 induces strong immune responses in hepatitis C DNA immunization.