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Haemophilus influenzae vaccine does not elicit helper T cells.

Vaccine Weekly

| March 03, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAR 3 - (NewsRx.com & NewsRx.net) -- The Haemophilus influenzae type b conjugate vaccine does not elicit antigen-specific helper T cells.

"A small number of fully vaccinated children in the U.K. have experienced invasive Haemophilus influenzae type b (Hib) infection. A rise in disease in recent years has been associated with lower vaccine-induced antibody levels over the first five years of life, forcing greater dependence on immunological memory for protection. This has necessitated the introduction of a catch-up campaign, designed to boost immunity in children aged six months to four years of age," researchers in England report.

"We suggest that the conjugate vaccine's inability to induce pathogen-specific helper T cells, combined with a loss of natural boosting due to reduced circulation of Hib, may have contributed to the rising incidence of invasive disease 10 years after introduction of the conjugate vaccine," said Jodie McVernon at the Communicable Disease Surveillance Centre, and collaborators at University College and the University of Oxford. "If so, the changing epidemiology of Hib infection in the UK may in part reflect ...

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