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DNA vaccines made from polymer time-bombs more potent.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Chun Wang and colleagues have incorporated DNA in a new formulation of biocompatible poly(ortho ester) micro-particles, the opening of which can be timed to occur with a specific delay, and only inside the sentry cells of the immune system. The delay gives the sentries the time they need to move from the tissue to the lymph nodes where they stimulate an immune response.
The study appears in the March 2004 issue of Nature Materials.
This sequence of events is crucial to the efficacy of DNA vaccines, because only in the lymph nodes can the antigens encoded by the DNA trigger the killer cells that defend the body. What's worse is that, if the antigens are made available before the sentries reach the lymph node, immune tolerance, the opposite of ...
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...were reported in the paper, "Molecularly engineered poly (ortho ester) microspheres for enhanced delivery of DNA vaccines," published...investigated the use of synthetic biodegradable polymers, poly (ortho ester) (POE) microspheres, specifically designed for enhancing...
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Source: HighBeam Research, DNA vaccines made from polymer time-bombs more potent.