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Cancer vaccines use high molecular weight stress proteins.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Scientists are developing cancer vaccines using autologous and recombinant high molecular weight stress proteins.
According to published research from the United States, "High molecular weight heat shock proteins (HSPs), hsp110 and grp170, derived from cancer cells have been previously shown to elicit tumor-specific immunity. This phenomenon is attributed to the antigenic peptides associated with the HSPs. Based on the unique chaperoning properties of these HSPs, a new vaccination strategy has been recently developed to elicit antigen-specific antitumor immunity."
"This approach utilizes tumor-associated antigens naturally complexed to these highly efficient molecular chaperones under heat shock conditions," said Xiang-Yang Wang and colleagues at Roswell Park Cancer Institute. "This chapter focuses on the methodologies of these two vaccine strategies: purification of hsp 110 and grp 170 from tumor tissue or cell lines, and generation and characterization of ...
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Source: HighBeam Research, Cancer vaccines use high molecular weight stress proteins.