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Tumor RNA-pulsed dendritic cells treat pancreatic tumors in mice.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Intratumoral immunization with tumor RNA-pulsed dendritic cells confers antitumor immunity in a C57BL/6 pancreatic murine tumor model.
"Pancreatic tumors lack adequate recruitment of immunocompetent cells, especially dendritic cells (DCs). We have shown previously that coculturing of natural killer-like T cells with DO transfected with pancreatic tumor cell line-derived RNA reverses pancreatic carcinoma cell resistance by directly triggering natural killer-like T lymphocytes in vitro," scientists in Germany report.
"In the present study, we tested triggering of specific T lymphocytes in vivo by using an immunocompetent mouse strain (C57BL/6)," said Tanja Schmidt and colleagues at Rheinische Friedrich-Wilhelms-Universitat in Bonn. "Syngenic, bone marrow-derived DCs were pulsed with tumor RNA derived from the pancreatic cell line PANC02. This cell line is a ductal pancreatic adenocarcinoma and shows high resistance to every known class of clinically active antitumor agent. PANC02 cells were implanted orthotopically via ultrasound guidance and led to pancreatic tumor formation in all of the mice. Thereafter, tumor RNA-pulsed DCs were injected intratumorally."
"Intratumoral administration of tumor RNA-pulsed DCs induced significantly more potent protective immunity than s.c. or i.v. ...
- Tumor RNA-pulsed dendritic cells treat pancreatic tumors in mice.
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Source: HighBeam Research, Tumor RNA-pulsed dendritic cells treat pancreatic tumors in mice.