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Measles virus expressing HIV proteins induces antibodies to HIV.
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- A single injection of recombinant measles virus vaccines expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses to HIV.
According to a study from France, "The anchored and secreted forms of the human immunodeficiency virus type 1 (HIV-1) 89.6 envelope glycoprotein, either complete or after deletion of the V3 loop, were expressed in a cloned attenuated measles virus (MV) vector. The recombinant viruses grew as efficiently as the parental virus and expressed high levels of the HIV protein. Expression was stable during serial passages. The immunogenicity of these recombinant vectors was tested in mice susceptible to MV and in macaques."
"High titers of antibodies to both MV and HIV-Env were obtained after a single injection in susceptible mice," reported Clarisse Lorin and colleagues at the Institut Pasteur in Paris. "These antibodies neutralized homologous SHIV89.6p virus, as well as several heterologous HIV-1 primary isolates. A gp160 mutant in which the V3 loop was deleted induced antibodies that neutralized heterologous viruses more efficiently than antibodies induced by the native envelope protein. A high level of CD8+ and CD4+ cells specific for HIV gp120 was also detected in MV-susceptible mice. ...
- Measles virus expressing HIV proteins induces antibodies to HIV.
- Newspaper article from: Biotech Week March 3, 2004 700+ words
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Source: HighBeam Research, Measles virus expressing HIV proteins induces antibodies to HIV.