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Arginine-glysine-aspartate motif enhances immunogenicity of antigens.
2004 FEB 18 - (NewsRx.com & NewsRx.net) -- The arginine-glysine-aspartate (RGD) motif enhances immunogenicity and adjuvanicity of peptide antigens following intranasal immunization.
"The use of peptides for various aspects of medical science has been a significant advance. Peptide-based vaccines are promising, but weak immunogenic potency is impeding the clinical application. We have remarkably enhanced the immunogenicity of peptide antigens by addition of motifs that bind to cell attachment proteins, such as arginine-glysine-aspartate (RGD), to the amino acid sequence," researchers in Japan report.
"The modified peptides induced antigen-specific serum antibodies by intranasal immunization without adjuvants," said Akira Yano and colleagues at the National Institute of Public Health in Tokyo. "RGD, an integrin-binding motif was the strongest, among several molecules tested in this experiment, giving an average of 10 times enhancement of antibody titers when incorporated into several peptide antigens. The peptides also acted as an efficient ...
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Source: HighBeam Research, Arginine-glysine-aspartate motif enhances immunogenicity of antigens.