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HBsAg variants break tolerance in hepatitis B surface antigen mice.
2004 FEB 18 - (NewsRx.com & NewsRx.net) -- Vaccination with cross-reactive, natural HBsAg variants breaks tolerance in hepatitis B surface antigen (HBsAg) transgenic mice.
"Processing exogenous hepatitis B surface antigen (HBsAg) of the hepatitis B virus (HBV) generates the K[superscript]b-binding S208-215 epitope 1; processing endogenous HBsAg generates the K[superscript]b-binding S190-197 epitope 2. Cross-reactive CD8+ T cell responses were primed to epitope 1 but not epitope 2 when mice were immunized with natural HBsAg[subscript]ayw, or HBsAg(adw2) variants differing within both epitopes by one or two residues. Expression of HBsAg[subscript]ayw from a transgene in the liver renders (HBs-tg) mice tolerant to epitope 1 of HBsAg[subscript]ayw," scientists writing in the European Journal of Immunology report.
"CD8+ T cells specific for epitope 1 could be primed in HBs-tg mice by HbsAg[subscript]adw2; these specific CD8+ T cells cross-reacted with epitope 1 processed from the transgene-encoded HBsAg[subscript]ayw," stated Reinhold Schirmbeck and collaborators at the University of Ulm and Rhein Biotech AG in Germany and the University of Copenhagen in Denmark. "The liver of vaccinated HBsAg[subscript]ayw transgenic mice showed severe histopathology and contained ...
- HBsAg variants break tolerance in hepatitis B surface antigen mice.
- Newspaper article from: Drug Week February 20, 2004 700+ words
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Source: HighBeam Research, HBsAg variants break tolerance in hepatitis B surface antigen mice.