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Broadly cross-reactive HIV-neutralizing antibody Fab identified.
2004 FEB 18 - (NewsRx.com & NewsRx.net) -- Researchers have identified a broadly cross-reactive HIV-neutralizing human monoclonal antibody Fab by sequential antigen panning of a phage display library.
"Identification of broadly cross-reactive human monoclonal antibodies (mAbs) has major implications for development of vaccines, inhibitors, and research tools. Here we describe a sequential antigen panning (SAP) methodology that may facilitate the selection of such antibodies. An HIV-specific antibody Fab (m18) was selected from a human Fab phage-display library by SAP against several recombinant soluble HIV envelope glycoproteins (Envs) and Env-sCD4 complexes," scientists in the United States report.
"This Fab bound to a variety of recombinant soluble Envs (gp140s) from primary HIV isolates representing different clades, and inhibited cell fusion and virus entry mediated by Envs of primary HIV isolates," stated Dimiter S. Dimitrov at the National Cancer Institute and collaborators in the United States. "The methodology and the results may have implications for development of HIV vaccines and inhibitors, as well ...
- Broadly cross-reactive HIV-neutralizing antibody Fab identified.
- Newspaper article from: Drug Week February 20, 2004 700+ words
...identified a broadly cross-reactive HIV...human monoclonal antibody Fab by sequential...Identification of broadly cross-reactive human...Immunological Methods (Broadly cross-reactive HIV...human monoclonal antibody Fab selected by sequential...
- Antibody Fab with human-like framework regions obtained from phage library.
- Newspaper article from: Immunotherapy Weekly September 1, 2004 700+ words
...Researchers have obtained a high-affinity macaque antibody Fab with human-like framework regions from a small phage display...study in Molecular Immunology (A high-affinity macaque antibody Fab with human-like framework regions obtained from a small...
- Recombinant antibody Fab blocks HCV adsorption to susceptible cells in vitro.
- Newspaper article from: Immunotherapy Weekly December 18, 2002 700+ words
...anti-HCV molecules, the researchers "cloned cDNAs of antibody Fab fragments from the mouse hybridoma cells secreting" 30F1...published their study in Antiviral Research (Recombinant antibody Fab against the hypervariable region 1 of hepatitis C virus blocks...
- Recombinant antibody Fab blocks HCV adsorption to susceptible cells in...
- Newspaper article from: Virus Weekly December 17, 2002 700+ words
...anti-HCV molecules, the researchers "cloned cDNAs of antibody Fab fragments from the mouse hybridoma cells secreting" 30F1...published their study in Antiviral Research (Recombinant antibody Fab against the hypervariable region 1 of hepatitis C virus blocks...
- Complex between Plasmodium protein and antibody Fab fragment described.
- Newspaper article from: Vaccine Weekly December 29, 2004 700+ words
...kDa protein Pvs25 and a malaria transmission-blocking antibody Fab fragment. According to recent research from the United States...kDa protein Pvs25 and a malaria transmission-blocking antibody Fab fragment. Acta Crystallogr D-Biol Cryst, 2004;60...
- Novavax Reports Positive Preclinical Results for a Novel, Broadly...
- Press release article from: PR Newswire February 19, 2009 700+ words
...human illness. "We believe that our recombinant VLP technology has the potential to be a powerful, new approach to develop broadly cross-protective vaccines. This approach may provide a viable strategy for pre-pandemic vaccination without an adjuvant and...
- Novartis investigational adjuvanted (MF59) pre-pandemic avian influenza vaccine...
- Newspaper article from: TB & Outbreaks Week May 19, 2009 700+ words
...pre-pandemic avian influenza vaccine formulated with Novartis' proprietary MF59® adjuvant, can elicit a broadly cross-reactive immune response covering all known H5N1 antigenic variants, even when that booster dose is administered six years...
- NCI investigators find CD4 t-cell protectors.(cluster of differentiation...
- Newspaper article from: AIDS Alert August 1, 2002 700+ words
...lab, we characterized extensively the properties of this antibody Fab and found its potent and broad neutralizing activity against...References 1. Moulard M; Phogat SK; Shu Y, et al. Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected...
