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Plant-produced colorectal cancer antigen developed.

Vaccine Weekly

| February 18, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 FEB 18 - (NewsRx.com & NewsRx.net) -- Researchers have developed a plant-derived colorectal cancer antigen.

According to recent research from the United States, "Cancer vaccination has become an important focus of oncology in recent years. Active immunization with tumor-associated antigens such as colorectal cancer antigen GA733-2 is thought to potentially overcome the reoccurrence of metastasis. As recombinant protein production in bioreactors is costly and subject to growing safety concerns, we tested plants as an alternative for the expression of a potential colorectal cancer vaccine."

"Comparing colorectal cancer antigen GA733-2 produced in tobacco plants with the same antigen produced in insect cell culture, we found a similar humoral immune response to injection of either of the two antigen preparations into mice," stated Thorsten Verch and colleagues at Thomas Jefferson University. "Some minor differences were observed in the cellular response that might be due to impurities. Our studies compare for the first time, immunization with the ...

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Source: HighBeam Research, Plant-produced colorectal cancer antigen developed.

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