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Bacterial spores as heat stable vaccine vehicles reviewed.

Vaccine Weekly

| February 11, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Researchers review bacterial spores as heat-stable vaccine vehicles.

According to published research from England, "Recently, the first use of bacterial spores as vaccine vehicles was reported, showing that mice orally immunized with Bacillus subtilis spores expressing a tetanus antigen could be protected against lethal challenge with tetanus toxin.

"Unlike many second-generation vaccine systems currently under development, none offer the heat stability of bacterial spores or the flexibility for genetic manipulation."

"The current use of Bacillus spores as probiotics for both humans and animals may facilitate their eventual licensing as oral vaccines," said Le H. Duc and Simon M. Cutting at the Royal Holloway University of London. "This review reports the progress that has been made in the establishment of bacterial spores as vaccine vehicles and outlines the ...

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Source: HighBeam Research, Bacterial spores as heat stable vaccine vehicles reviewed.

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