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Researchers map pneumococcal surface protein A of strain Rx1.
2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Researchers have performed epitope mapping of pneumococcal surface protein A of strain Rx1 using monoclonal antibodies and molecular structure modeling.
"Pneumococcal surface protein A (PspA) is an antigenic variable vaccine candidate of Streptococcus pneumoniae. Epitope similarities between PspA from the American vaccine candidate strain Rx1 and Norwegian clinical isolates were studied using PspA specific monoclonal antibodies (mAbs) made against clinical Norwegian strains. Using recombinant PspA/Rx1 fragments and immunoblotting the epitopes for mAbs were mapped to two regions of amino acids, 1-67 and 67-236," scientists in Norway and the United States report.
"The discovered epitopes were visualized by modeling of the PspA:Fab part of mAb in three dimensions," said Jan Kolberg and collaborators at the Norwegian Institute of Public Health and Children's Hospital Oakland in the U.S.
"Flow cytometric analysis showed that the epitopes for majority of mAbs were accessible for antibody binding on live pneumococci. ...
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- Researchers map pneumococcal surface protein A of strain Rx1.
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