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IL-10 regulates immune responses induced by schistosome vaccine.
2004 FEB 11 - (NewsRx.com & NewsRx.net) -- IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine.
According to recent research from England, "Radiation-attenuated (RA) schistosomes penetrate the host via the skin where they stimulate intense inflammatory reactions and the release of pro-inflammatory IL-12, important for Th1-type immune responses which are partially host protective. However, RA larvae also induce the secretion of regulatory IL-10. We now show that following vaccination of IL-12p40[superscript]-/- mice, abundant IL-10 was produced by in vitro cultured skin biopsies between days 4 and 14, corresponding to the down-regulation of MHC II expression by cells in the dermis and cells that emigrate from the skin."
"In IL-10[superscript]-/- mice, inflammation of the vaccination site was increased with larger numbers of IL-12p40+, MHC II+ and CD86+ cells in the dermal exudate, and was associated with elevated levels of skin-derived IL-12p40 and IL-1beta," reported Karen G. Hogg and colleagues at the University of York. "These changes in IL-10[superscript]-/- mice were also reflected by an increased number of cells in the skin-draining lymph nodes (sdLN) and greater levels of lymphocyte proliferation. Moreover, such mice had increased numbers of CD4+ sdLN cells that were CD25+, CD28+, or CD152+ and accessory cells that were CD40+ or MHC II+."
"Finally, the secretion of ...
- IL-10 regulates immune responses induced by schistosome vaccine.
- Newspaper article from: Medical Letter on the CDC & FDA February 15, 2004 700+ words
...regulates early IL-12-mediated immune responses induced by the radiation...pro-inflammatory IL-12, important for Th1-type immune responses which are partially...regulates early IL-12-mediated immune responses induced by the radiation...
- IL-23 induces strong immune responses in hepatitis C DNA immunization.
- Newspaper article from: Virus Weekly March 2, 2004 700+ words
...sustained CTL and Th1 immune responses than does IL-12 after hepatitis...are much stronger than IL-12-mediated immune responses," said Sang-Jun Ha...sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus...
- IL-6 gene and CpG motifs regulate immune responses to trivalent vaccines.
- Newspaper article from: Biotech Week August 25, 2004 700+ words
...lymphocytes and induced IL-2 activities were significantly...The above-mentioned immune responses of mice co-inoculated...suggest that the porcine IL-6 gene and CpG motifs...gene and CpG motifs on immune responses to porcine trivalent...
- Immune responses may lead to induction of T cell IL-12/IL-18 responsiveness.
- Newspaper article from: Immunotherapy Weekly April 16, 2003 700+ words
...NewsRx.net) -- Immune responses may lead to induction of T cell IL-12/IL-18 responsiveness...responsiveness via IL-12 production operates...Immunotherapy (A series of immune responses leading to the induction of T cell IL-12/IL-18 responsiveness...
- Pseudovirus encoding IL-2 restores immune responses to vaccines.
- Newspaper article from: Biotech Week October 20, 2004 700+ words
...pseudovirus encoding IL-2 fully restores mucosal and systemic immune responses to vaccinations...cells to produce IL-2. We used papillomavirus...address how to enhance immune responses to vaccinations...pseudovirus encoding IL-2 fully restores mucosal and systemic ...
- IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When...
- Newspaper article from: Vaccine Weekly July 12, 1999 700+ words
...Staats, H.F.; Ennis, F.A. "IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When Coadministered With Protein Immunogens...produce the proinflammatory cytokines IL-1, IL-6, and IL-8 and up...
- Measles virus expressing IL-12 alters immune responses in macaques.
- Newspaper article from: Immunotherapy Weekly January 14, 2004 700+ words
...humoral and cellular immune responses. "Lack of a vaccine...Because interleukin (IL)-12 has been used...concluded, "Reduced IL-12 levels are not the...humoral and cellular immune responses. J Infec Dis, 2003...60th Street, Chicago, IL 60637-2954, USA...
- Adenovirus-Mediated Expression in Rat Liver of IL-4, But Not IL-10 or TGFb1,...
- Newspaper article from: Immunotherapy Weekly July 13, 1998 700+ words
...Expression in Rat Liver of IL-4, But Not IL-10 or TGFb1, Induces...Enhanced Anti-Adenovirus Immune Responses." A. David, J. Chetriff...increased anti-adenovirus immune responses and produced a moderate...directly mediated by IL-4."