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Pathway for cell-associated antigens by dendritic cells characterized.
2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Researchers have characterized the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells.
According to published research from the United States, "Major histocompatibility complex (MHC) class I presentation of exogenous antigens is the mechanism enabling professional antigen-presenting cells (APCs) to induce CD8+ T-cell responses against viruses and tumors that do not have access to the classical MHC class I pathway. We have characterized the uptake, processing, and MHC class I cross-presentation by human dendritic cells (DCs) of cell-associated antigens derived from physiologically relevant sources, namely, vaccinia virus-infected apoptotic and necrotic cells."
"We show that cross-presentation is a rapid process, detectable within two to four hours after uptake of dead cells, and that proteolysis by cathepsin D in an acidic endosomal compartment is essential for cross-presentation," said Jean Francois Fonteneau at INSERM U453 in France and collaborators in the United States and Sweden. "The presentation is abolished when the phagocytic or macropinocytic functions of the cells are inhibited and is dependent on ...
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...deliver tumor antigens to dendritic cells (DCs) for cancer immunotherapy...restricted epitope SIINFEKL for MHC class I presentation." "In contrast...expressing OVA alone were used, MHC class II presentation of the OVA...coli vaccine to promote MHC class I-dependent ...
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...their ability to load MHC class II molecules," reported...are channeled into the MHC class II presentation pathway...of T cell epitopes for MHC class II presentation. Int...major subject areas of Dendritic Cells, Immunology, and Antibody...
Source: HighBeam Research, Pathway for cell-associated antigens by dendritic cells characterized.