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Inactivated split influenza vaccine safe in children with asthma.
2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Inactivated split influenza vaccine is safe in children with stable asthma.
"Although annual influenza vaccinations are recommended by many authorities, some doctors may be reluctant to vaccinate asthmatic children because of the risk of inducing bronchial reactivity and exacerbating the asthma. In this study, the effect of split influenza vaccine on clinical symptoms, airway responsiveness, and its influence on T lymphocytes was evaluated. Twenty-one asthmatic children with stable asthma were recruited and divided into two groups," researchers in Taiwan report.
"Eleven patients who received the influenza vaccine formed the vaccination group and 10 patients who received a placebo formed the placebo group," stated Wen-Jen Chiu and colleagues at Chuang Gung Children's Hospital. "Forced expiratory volume in 1 s (FEV[subscript]1), airway response (PC[subscript]20 methacholine, PC[subscript]20=provocation concentration causing a 20% fall in FEV[subscript]1) and the T lymphocyte subset ratio (Th1/Th2) were recorded on day 1 pre-vaccination and day 14 post-vaccination. Patients were also asked to record their peak expiratory flow (PEF) every morning and evening and to complete daily symptom scores over the period of two weeks."
"There were no significant changes in PC[subscript]20, FEV[subscript]1, PEF variability, symptom scores, and the Th1/Th2 ratio between the vaccination and placebo groups between day ...
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