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HEV-neutralizing antibodies recognize antigen of ORF2 protein vaccine.
2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Monoclonal antibodies that neutralize hepatitis E virus (HEV) recognize an antigenic site at the carboxyterminus of an ORF2 protein vaccine.
According to recent research published in the journal Vaccine, "In order to obtain monoclonal antibodies that might have prophylactic applications and to understand better the immune response to hepatitis E virus (HEV), we used phage display to isolate chimpanzee antibodies to HEV."
"The panning antigen was a two open reading frame (ORF2) recombinant protein that elicits a broadly protective immune response in vaccinated monkeys," said Darren J. Schofield and colleagues at the U.S. National Institute of Allergy & Infectious Diseases. "Two major antigenic sites were identified on the ORF2 protein: one site was not accessible on the surface of infectious virions but the other site was accessible to antibodies and was recognized specifically by antibodies that neutralize the virus."
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