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RANK-L gene improves the T cell immune response to infectious agents.
2004 FEB 11 - (NewsRx.com & NewsRx.net) -- Scientists describe a potent adjuvant effect of ligand to receptor activator of the NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination.
According to research from Japan, "The ligand to receptor activator of NF-kappaB (RANK-L)/ RANK interaction has been implicated in CD40 ligand/CD40-independent T cell priming by dendritic cells. In this report, we show that the co-administration of the RANK-L gene with a Trypanosoma cruzi gene markedly enhances the induction of Trypanosoma antigen-specific CD8+ T cells and improves the DNA vaccine efficacy."
"A similarly potent adjuvant effect of the RANK-L gene on the induction of antigen-specific CD8+ T cells was also observed when recombinant influenza virus expressing murine malaria antigen was used as an immunogen," reported Yasushi Miyahira and collaborators at Juntendo University, Tokyo Medical and Dental University, and Keio University. "In contrast, the co-administration of the CD40L gene was not effective in these systems. Our results demonstrated, for the first ...
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Source: HighBeam Research, RANK-L gene improves the T cell immune response to infectious agents.