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GnRH antagonist is effective when administered on day 1 of ovarian stimulation.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- GnRH antagonist is effective when administered on day 1 of ovarian stimulation.
According to new research from Belgium, "the objective of the present study was to assess the effect of altering the timing of GnRH antagonist initiation on the hormonal environment and follicular development in in vitro fertilization cycles. Sixty women undergoing in vitro fertilization participated in a prospective randomized controlled trial. Patients were stimulated with a fixed dose of 200 IU recombinant FSH, starting on day (d) 2 of the cycle, and with GnRH antagonist, starting either on d 1 (n = 30) or on d 6 of stimulation (n = 30)."
"A significantly lower exposure to LH (p
"Similar fertilization rates, implantation rates, and ongoing pregnancy rates per transfer were, in addition, present between the two groups compared."
"In conclusion, administration of GnRH antagonist on d 1 (compared with d 6) of stimulation is associated with a lower exposure to LH and estradiol, which does not seem to affect follicular development," investigators stated.
Kolibianakis and colleagues published the results of their research in Journal of Clinical Endocrinology and Metabolism (Initiation of gonadotropin-releasing hormone antagonist on day ...
- GnRH antagonist is effective when administered on day 1 of ovarian stimulation.
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