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Platelet-activating factor stops enzyme secretion in decidual macrophages.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Platelet-activating factor stops enzyme secretion in decidual macrophages.
According to recent research from Japan, "to clarify the role of platelet-activating factor (PAF) in parturition, the effects of PAF on the secretion of PAF-acetylhydrolase (PAF-AH), a PAF-inactivating enzyme, by decidual macrophage populations were examined. The cells were isolated from human decidual tissue by enzymatic digestion, Ficoll-Paque centrifugation, or flow cytometric sorting. The nonhydrolyzable agonist of PAF, carbamyl-PAF (C-PAF), inhibited the secretion of PAF-AH by either decidual cells or flow cytometrically purified decidual macrophages."
"A specific PAF receptor antagonist, WEB 2086, blocked the C-PAF-induced inhibition. Lyso-PAF, a metabolite of PAF, had no effect on the enzyme secretion. An intracellular calcium channel blocker, bis-(o-aminophenoxy)-ethane-N, N, N', N'-tetraacetic acid, tetra( acetoxymethyl)-ester, partially blocked the inhibition by C-PAF, whereas extracellular calcium channel blockers, nifedipine and verapamil, were without effect," according to H. Narahara and colleagues, Oita Medical University, Department of Obstetrics and Gynecology.
"The inhibitory effect of C-PAF was also partially blocked by protein kinase C (PKC) ...
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