AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
The SHBG gene might make women vulnerable to polycystic ovary syndrome.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- The SHBG gene might make women vulnerable to polycystic ovary syndrome.
According to published research from Greece, "Sex hormone-binding globulin SHBG levels are frequently low in women with polycystic ovary syndrome (PCOS) and may contribute to increased tissue exposure to free androgens. A (TAAAA) n repeat polymorphism in the promoter of the SHBG gene has been described recently, and its transcriptional activity has been shown to be related to the number of tandem repeats. Recent evidence also suggests that prenatal exposure to androgen excess may program for the development of the PCOS phenotype during adulthood."
"Our aim was to investigate the possible association of the functional (TAAAA) n polymorphism in the promoter of the SHBG gene with PCOS and its relation to SHBG levels. We studied 185 women with PCOS and 324 normal controls. Genotype analysis revealed six (TAAAA) n alleles containing 6 - 11 repeats. The distribution of these alleles was different in the two groups," according to N. Xita and colleagues, University of Ioannina, Department of Medicine.
"Women with PCOS had a significantly greater frequency of longer (TAAAA) n alleles (more than eight repeats) than normal women who had shorter alleles (less than eight repeats) in higher frequency (p=0.001). Furthermore, in the PCOS group, carriers of the longer allele genotypes had lower SHBG levels [1.17[+ or -]0.68 microgram/dl (35.1[+ or -]20.5 nmol/liter)] than those with shorter alleles [1.51[+ or -]0.93 microgram/dl ...
- Interviews alone can't predict polycystic ovary syndrome status.
- Newspaper article from: Biotech Week February 4, 2004 700+ words
...Interviews alone can't predict polycystic ovary syndrome status. "Polycystic ovary syndrome (PCOS), a leading cause of female...interview for predicting the presence of polycystic ovary syndrome. Gynecol Endocrinol, 2003;17...
- Polycystic ovary syndrome (Stein-Leventhal Syndrome).(Disease/Disorder overview)
- Clinical Reference Systems January 1, 2006 700+ words
What is polycystic ovary syndrome? Polycystic ovary syndrome (PCOS) is a hormone disorder that causes many small benign cysts to form on the ovaries under a thick, white covering, which prevents the release of an egg. It causes your menstrual...
- Polycystic Ovary Syndrome Treated with New Approach in Stanford Study.
- Press release article from: Business Wire June 16, 2004 700+ words
...effective at treating symptoms of polycystic ovary syndrome, according to a Stanford University...metabolic and ovarian abnormalities in polycystic ovary syndrome," said Cataldo. Polycystic ovary syndrome, or PCOS, is characterized by...
- Suitability of recommended limits for fasting glucose tests in women with...
- Magazine article from: Canadian Medical Association. Journal Gagnon, Claudia; Baillargeon, Jean-Patrice March 27, 2007 700+ words
...tolerance among women with polycystic ovary syndrome when their fasting plasma...tolerance in women with polycystic ovary syndrome, and then to define the...consecutive women with polycystic ovary syndrome referred to an academic...
- Polycystic Ovary Syndrome
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Fallon, L. January 1, 2006 700+ words
Polycystic Ovary Syndrome Definition Polycystic ovary syndrome (PCOS) is a condition characterized by the accumulation of numerous cysts (fluid-filled sacs) on the ovaries associated with high male hormone levels, chronic anovulation (absent...
- Homocysteine levels are unaffected by metformin treatment in both nonpregnant...
- Magazine article from: Alternative Medicine Review Carlsen, S.M. Kjotrod, S. Vanky, E. Romundstad, P. June 1, 2007 700+ words
...BACKGROUND: Women with polycystic ovary syndrome have elevated homocysteine...complications. Women with polycystic ovary syndrome are often treated with...and pregnant women with polycystic ovary syndrome. METHODS: Two prospective...
- Polycystic ovary syndrome gets redefined diagnosis.
- Magazine article from: Contraceptive Technology Update April 1, 2004 700+ words
Polycystic ovary syndrome gets redefined diagnosis A...initial diagnosis? If it is polycystic ovary syndrome (PCOS), your deduction falls...hyperandrogenic women have polycystic ovary syndrome. Clinical manifestations of...
- Screening for diabetes in women with polycystic ovary syndrome
- Magazine article from: Canadian Medical Association. Journal Lau, David C W March 27, 2007 700+ words
Polycystic ovary syndrome is a common hormonal disorder...role in the pathophysiology of polycystic ovary syndrome and its associated metabolic...of overweight and obesity, polycystic ovary syndrome is increasingly recognized...