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New research explains why only intermittent parathyroid hormone grows new bone.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- New research explains why only intermittent parathyroid hormone grows new bone.
"It is unknown why sustained elevation of parathyroid hormone (PTH) stimulates bone resorption, whereas intermittent administration stimulates bone formation. We show in mice that daily injections of PTH attenuate osteoblast apoptosis, thereby increasing osteoblast number, bone formation rate, and bone mass, but do not affect osteoclast number. In contrast, sustained elevation of PTH, achieved either by infusion or by raising endogenous hormone secretion with a calcium-deficient diet, does not affect osteoblast apoptosis but increases osteoclast number," scientists in the United States report.
"Attenuation of apoptosis by PTH in cultured osteoblastic cells requires protein kinase A-mediated phosphorylation and inactivation of the proapoptotic protein Bad as well as transcription of survival genes, like Bcl-2, mediated by CREB (cAMP response element-binding protein) and Runx2," according to T. Bellido and colleagues, University of Arkansas for Medical Sciences, Division of Endocrinology and Metabolism.
"But, PTH also increases proteasomal proteolysis of Runx2. Moreover, the antiapoptotic effect of PTH is prolonged by inhibition of proteasomal activity, by overexpressing a dominant negative form of the E3 ligase (ubiquitin-protein isopeptide ligase) that targets Runx2 for degradation ...
- Postop PTH test unnecessary when calcium is normal.(Metabolic...
- Magazine article from: Family Practice News Evans, Jeff May 1, 2006 700+ words
...from routine measures of parathyroid hormone unless they have elevated...recommend checking the [parathyroid hormone] level," said Dr. Yen...found routine postoperative parathyroid hormone (PTH) testing of questionable...
- NPS Comments on Interim Results of PaTH Study Data; Results Indicate...
- Press release article from: PR Newswire September 20, 2003 700+ words
...presented today suggest that parathyroid hormone (PTH 1- 84) may be more effective...effect of the sequential use of PTH and alendronate. About Preos...produced, full-length human parathyroid hormone (PTH). The importance of calcium...
- PTH appropriate for a select few patients with bone loss.(Metabolic...
- Magazine article from: Family Practice News Kirn, Timothy F. April 1, 2006 700+ words
...who should be treated with parathyroid hormone, Dr. Lenore Buckley said...who are proper candidates for parathyroid hormone (PTH) therapy, according to a...with alendronate, 2 years of PTH therapy, and 2 years of PTH...
- PTH then alendronate shows synergistic effect: reverse sequence doesn't...
- Magazine article from: Family Practice News Jancin, Bruce March 15, 2004 700+ words
...COLO. -- Sequential use of recombinant parathyroid hormone followed by an antiresorptive agent is...therapy with alendronate first, followed by parathyroid hormone (PTH), seems to attenuate PTH's ability to increase bone mineral density...
- Quest Diagnostics Receives FDA Clearance For New Bio-Intact PTH Parathyroid...
- Press release article from: PR Newswire January 8, 2002 700+ words
...its new Bio-Intact PTH (1-84) proprietary...test kit to measure parathyroid hormone, essential in the assessment...cleared Bio-Intact PTH test kit is available...Diagnostics. The Bio-Intact PTH test is the first fully...recognize the entire parathyroid hormone molecule, rather ...
- PTH response may explain higher BMD in blacks.(Metabolic Disorders)(parathyroid...
- Magazine article from: Family Practice News Evans, Jeff January 15, 2007 700+ words
...resorption, and response to parathyroid hormone, Dr. Felicia Cosman said...470-3). In many studies, parathyroid hormone (PTH) levels are higher, on average...blacks than in whites. The PTH levels found in blacks occur...
- PTH and ionized calcium.(Lab Professionals Pose Challenging...
- Magazine article from: Medical Laboratory Observer Orwoll, Eric April 1, 2004 700+ words
...chemistry lab is attempting to bring up parathyroid hormone (PTH) testing. Method validation data...interpretation. He believes that a PTH should be interpreted with an ionized calcium. I have researched PTH and can only find PTH results reported...
- PTH's promise. (News & Clinical Trials Results).(parathyroid hormone)
- Newspaper article from: New Medical Therapies -- Osteoporosis June 22, 2000 700+ words
Parathyroid hormone (PTH) is showing promise as a bone-forming...at least one year, half also received PTH. The women on the combination therapy...to increase bone size and bone mass, PTH could contribute to fracture prevention...
- Sex hormones mediate effect of PTH in men.(Metabolic Disorders)(parathyroid...
- Magazine article from: Family Practice News Wachter, Kerri January 15, 2006 700+ words
...bone-resorbing properties of parathyroid hormone (PTH) in men. It's not clear whether...All men underwent infusions of PTH (1-34) at baseline and at 6...Mean NTx levels measured prior to PTH infusion did not change between...
- Quest Diagnostics (Teterboro, New Jersey) said its test manufacturing unit....
- Newspaper article from: The BBI Newsletter February 1, 2002 700+ words
...market the Bio-Intact PTH (1-84) diagnostic test kit to measure parathyroid hormone, essential to assess...health. The Bio-Intact PTH test kit is available...called the Bio-Intact PTH test the first fully...recognize the entire parathyroid hormone molecule, rather than...
Source: HighBeam Research, New research explains why only intermittent parathyroid hormone grows...