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Low vitamin D and high parathyroid hormone cause sarcopenia in older people.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Low vitamin D and high parathyroid hormone cause sarcopenia in older people.
"The age-related change in hormone concentrations has been hypothesized to play a role in the loss of muscle mass and muscle strength with aging, also called sarcopenia. The aim of this prospective study was to investigate whether low serum 25-hydroxyvitamin D (25-OHD) and high serum PTH concentration were associated with sarcopenia. In men and women aged 65 years and older, participants of the Longitudinal Aging Study Amsterdam, grip strength (n=1008) and appendicular skeletal muscle mass (n=331, using dual-energy x-ray absorptiometry) were measured in 1995 - 1996 and after a 3-year follow-up," scientists writing in the Journal of Clinical Endocrinology and Metabolism reported.
"Sarcopenia was defined as the lowest sex-specific 15th percentile of the cohort, translating into a loss of grip strength greater than 40% or a loss of muscle mass greater than 3%," said M. Visser and colleagues, Free University of Amsterdam, Medical Center.
"After adjustment for physical activity level, season of data collection, serum creatinine concentration, chronic disease, smoking, and body mass index, persons with low ( <25 nmol/liter) baseline 25-OHD levels were 2.57 (95% confidence interval 1.40 - 4.70, based on grip strength) and 2.14 (0.73 - 6.33, based on muscle mass) times more likely to experience sarcopenia, compared with those with high (>50 nmol/liter) levels."
"High PTH levels (greater than or equal to4.0 pmol/liter) were associated with an increased risk of sarcopenia, compared with low PTH (
"The results of this prospective, population-based study show that lower 25-OHD ...
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Source: HighBeam Research, Low vitamin D and high parathyroid hormone cause sarcopenia in older...