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Extra VEGF that is produced during fasting suggests nutritional regulation.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Extra VEGF produced during fasting suggests nutritional regulation.
"The aim of this study was to investigate the effect of fasting on both vascular endothelial growth factor (VEGF) production and VEGF mRNA expression in growing ovarian follicles (>5 mm in diameter) from gilts at 48 hours (h) after equine chorionic gonadotrophin (eCG) treatment. The concentrations of VEGF and albumin were measured in the follicular fluid of single follicles, and VEGF mRNA was determined in the follicle wall," according to scientists in Italy.
"Fasting resulted in a significant increase in VEGF concentrations in follicular fluid (20.64[+ or -]0.72 versus 10.79[+ or -]0.86 ng ml[superscript]-1, p
"The concentrations of albumin measured in follicular fluid as an index of vessel permeability were higher in fasted than in animals fed normally, most likely as a result of the increased VEGF production. Follicular steroidogenesis was impaired in fasted animals. Progesterone was the most abundant steroid in the follicular fluid and estradiol was present in lower concentrations, thus indicating an alteration in the steroidogenic enzymatic cascade."
"In conclusion, fasting induces an increase in both VEGF production and vessel permeability. Such a reaction is unable under severe food deprivation to preserve follicle function, but may represent a ...
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Source: HighBeam Research, Extra VEGF that is produced during fasting suggests nutritional...