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Steroid hormone-resistant breast cancer can be sensitive to growth factors.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers establish numerous regulatory links between signal transduction pathways elicited by peptide growth factors and progesterone receptors (PR).
"Breast cancers often have increased mitogen-activated protein kinase (MAPK) activity; this pathway influences breast cancer cell growth in part by targeting steroid hormone receptors," scientists in the United States report.
"Bidirectional cross-talk between these two pathways is well documented; progestins increase the expression of type I growth factor receptors that couple to MAPK activation, and in turn, activation of p42 and p44 MAPKs increases ligand-dependent progesterone receptor (PR) transcriptional activity, and parodoxically, augments PR downregulation. Breast cancers that have become steroid hormone resistant often remain highly sensitive to growth factors," wrote M. Qiu and colleagues, University of Minnesota Cancer Center.
"We believe that the mechanism of steroid hormone resistance is biochemically linked to the acquisition of growth factor responsiveness. Using in vitro models, we have established numerous regulatory links between signal transduction pathways elicited by peptide growth factors and PR. Of note is the role of phosphorylation of human PRs by MAPKs," the researchers wrote.
"Phosphorylation of PR on a key serine residue (Ser294) by MAPKs couples multiple receptor functions, including ligand-dependent PR ...
- Steroid hormone-resistant breast cancer can be sensitive to growth factors.
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- Stress modality influences steroid hormone responses in male rats.
- Newspaper article from: Obesity, Fitness & Wellness Week August 14, 2004 700+ words
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- Specific RNA motifs required for coactivation of steroid hormone receptors.
- Newspaper article from: Gene Therapy Weekly February 13, 2003 700+ words
...functions as a eukaryotic transcriptional coactivator for steroid hormone receptors. We report here the isolation and functional...Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA). Proc...
- Industry Associations Applaud Passage of Biden/Hatch Legislation Placing...
- Press release article from: PR Newswire October 12, 2004 700+ words
...a bill introduced by Senators Joseph Biden (D-Del.) and Orrin Hatch (R-Utah), that provides for the listing of steroid hormone precursors such as androstenedione ("andro") under the Controlled Substances Act. Such action effectively prohibits...
