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Side effects make physicians, patients reluctant to use tamoxifen for DCIS.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Physicians and patients alike are reluctant to use tamoxifen, an adjuvant therapy in the treatment of the very earliest form of breast cancer - ductal carcinoma in situ (DCIS) - because of its side effects, potential complications, and marginal efficacy, according to study findings.
Tamoxifen is an estrogen hormone-regulating drug used to prevent recurrence of breast cancer after surgery. It has been shown to decrease mortality in women with invasive breast cancer. However, in the landmark 1999 study called the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-24, tamoxifen was tested in women with DCIS following breast-conserving surgery. In contrast to invasive breast cancers, the absolute risk reduction for cancer recurrence was marginal at only 5% in patients with DCIS, and there was no reduction in mortality.
Studies have also shown that tamoxifen increases the risk of endometrial cancer and thromboembolic events, such as pulmonary emboli, particularly in postmenopausal women. Other potential side effects include hot flashes, vaginal bleeding, and cataract formation.
To evaluate the impact of the NSABP B-24 trial on current clinical ...
- Side effects make physicians, patients reluctant to use tamoxifen for DCIS.
- Newspaper article from: Biotech Week February 4, 2004 700+ words
...carcinoma in situ (DCIS) - because of its side effects, potential complications...Other potential side effects include hot flashes...clinical practice of DCIS, a team of investigators...These same side effects led to a high...treatment for DCIS still taking...
- A TIME TO DECIDE: Detections of DCIS breast cancer are increasing. So are...
- Magazine article from: Newsweek Kalb, Claudia February 28, 2000 700+ words
...especially virulent areas of DCIS. But many experts now believe...cut the risk of developing a DCIS recurrence or an invasive cancer...radiation--which can cause side effects like skin irritation and fatigue...attempting to identify the best DCIS patients for radiation-free...
- Women with DCIS need to be better educated about treatment choices.
- Newspaper article from: Medical Devices & Surgical Technology Week April 18, 2004 700+ words
...cancer, a growth in the milk ducts called DCIS. Diagnosed in over 55,000 women a year...fact, it's very different. Removing DCIS prevents invasive breast cancer, the kind...of patients originally diagnosed with DCIS die of breast cancer in the next 10 years...
- Radiation reduces DCIS recurrence. (ductal carcinoma in situ)
- Newspaper article from: HealthFacts July 1, 1993 700+ words
...screening. Ductal carcinoma in situ (DCIS) was once routinely treated with mastectomy...mastectomies on those with stage O, which is how DCIS is sometimes described. [See HealthFacts...there has been a slow trend toward treating DCIS less radically, either with lumpectomy...
- Anxiety Linked to Newly Diagnosed DCIS Patients' Overestimation of Breast...
- News wire article from: Ascribe Higher Education News Service February 12, 2008 700+ words
...cause women with ductal carcinoma in situ (DCIS), the most common form of non-invasive...Cancer Institute in Boston. "Although DCIS typically is very treatable disease, many women diagnosed with DCIS develop inaccurate risk perceptions...
- Surgery without radiation inadequate for DCIS, study shows.
- Magazine article from: Women's Health Weekly December 25, 2003 700+ words
...surgery for ductal carcinoma in situ (DCIS) experienced recurrences at a surprisingly...prospective study to evaluate the hypothesis that DCIS (a common type of breast lesion that is...alone proved to be effective, women with DCIS could be spared the inconvenience of daily...
- Surgery Without Radiation Inadequate for DCIS, Study Reveals; Recurrences...
- News wire article from: Ascribe Higher Education News Service December 3, 2003 700+ words
...surgery for Ductal Carcinoma In Situ (DCIS) experienced recurrences at a surprisingly...prospective study to evaluate the hypothesis that DCIS (a common type of breast lesion that is...alone proved to be effective, women with DCIS could be spared the inconvenience of daily...
- Protein predicts development of invasive breast cancer in women with DCIS, Penn...
- Newspaper article from: Cancer Vaccine Week June 8, 2009 700+ words
Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2...Prevention, may help clinicians distinguish between DCIS that requires minimal treatment and DCIS that should be treated more aggressively (see also...
