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Sequential drugs followed by TRAIL may be a new therapeutic approach for cancer.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Researchers report that sequential administration of chemotherapeutic drugs followed by TRAIL may be an effective new therapy for cancer.
"According to published research from the United States, "Tumor necrosis factor-related apoptosis-inducing-ligand (TRAIL/Apo-2 ligand) induces apoptosis in the majority of cancer cells without appreciable effect in normal cells. Here, we report the effects of TRAIL on apoptosis in several human breast cancer cell lines, primary memory epithelial cells, and immortalized nontransformed cell lines, and we examine whether chemotherapeutic agents augment TRAIL-induced cytotoxicity in breast cancer cells in vitro and in vivo.
"TRAIL induced apoptosis with different sensitivities, and the majority of cancer cell lines were resistant to TRAIL. The chemotherapeutic drugs (paclitaxel, vincristine, vinblastine, etoposide, camptothecin, and Adriamycin) induced death receptors (DRs) TRAIL receptor 1/DR4 and TRAIL receptor 2/DR5, and successive treatment with TRAIL resulted in apoptosis of both TRAIL-sensitive and -resistant cells," wrote T.R. Singh and colleagues, University Maryland, Department of Pharmaceutical Science.
"Actinomycin D sensitized TRAIL-resistant cells through up-regulation of caspases (caspase-3, -9, and -8). TRAIL induces apoptosis in Adriamycin-resistant MCF7 cells already expressing high levels of death receptors DR4 and DR5. The pretreatment of breast cancer cells with chemotherapeutic drugs followed ...
- Natural compounds, chemotherapeutic drugs may become partners in cancer therapy.
- Newspaper article from: NewsRx Health & Science October 4, 2009 700+ words
...found. This is also the mechanism of action of hydroxyurea, one drug already being used for cancer chemotherapy. "In cancer research right now there's interest in approaches that can reduce ribonucleotide reductase," Dashwood said. "At the doses used...
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- News wire article from: US Fed News Service, Including US State News September 3, 2009 700+ words
...found. This is also the mechanism of action of hydroxyurea, one drug already being used for cancer chemotherapy. "In cancer research right now there's interest in approaches that can reduce ribonucleotide reductase," Dashwood said. "At the doses used...
- Applied DNA Systems Inc. announces agreement with Mitsubishi-Yuka Laboratory of...
- Press release article from: PR Newswire May 11, 1987 700+ words
...for determining the sensitivity of human cancers to chemotherapeutic drugs. Donald M. Bachmann, chairman of Applied DNA Systems...exposed to a fluorescent substance and then treated with chemotherapeutic drugs for several days. If the cells no longer fluoresce...
- Reducing the risks: healthcare workers who come into contact with...
- Magazine article from: Cancer Nursing Practice Roberts, Rosie May 1, 2003 700+ words
...odds ratio (OR = 1.5; CI = 1.1 to 2.0) for self-reported infertility associated with handling of chemotherapeutic drugs prior to onset of infertility (Valanis et al 1997). The risk to healthcare staff has not always been recognised...
- Cancer treatment and memory loss. (research shows high doses of toxic...
- Magazine article from: Science News Fackelmann, Kathleen February 21, 1998 700+ words
...van Dam of the Netherlands Cancer Institute in Amsterdam and his colleagues report that high doses of toxic chemotherapeutic drugs may raise the risk of cognitive deficits. Van Dam's team studied 34 breast cancer patients treated with...
- Preclinical Studies Show Cell Pathways' Exisulind is Synergistic With...
- Press release article from: Business Wire May 18, 1999 700+ words
...demonstrating synergy between the company's lead investigational drug, exisulind, and chemopreventive and chemotherapeutic drugs in both cell culture and animal models of lung cancer. The new findings were presented today by Cell Pathways...
- New esophageal cancer research from L. Xie et al outlined.
- Newspaper article from: Cancer Weekly August 4, 2009 700+ words
...certain kind of chemotherapeutic drugs," wrote L...amp; Clinical Cancer Research (Fractionated...more sensitive to chemotherapeutic drugs. Journal of Experimental...amp; Clinical Cancer Research, 2009;28...
- Studies from Japanese Foundation for Cancer Research provide new data on cancer...
- Newspaper article from: Cancer Weekly November 3, 2009 700+ words
...the efflux of chemotherapeutic drugs and increases...Foundation for Cancer Research (see also Cancer...population cells to chemotherapeutic drugs by inhibiting...Foundation for Cancer Research, Japanese Foundation...