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P1 homozygosity may be a potential risk factor in breast carcinogenesis.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Research suggests that P1 homozygosity could possibly be a risk factor in breast carcinogenesis.
According to a study from Greece, "H-ras is a member of the ras superfamily of genes. This gene encodes for a 21 kDa protein (p21), which is located on the inner surface of the plasma membrane. Ras genes are involved in a wide variety of human tumors, and there is a known correlation between H-ras activation and breast carcinogenesis."
"H-ras contains a polymorphic region, a repeated hexanucleotide -GGGCCT - located in intron 1 close to the 5' of the gene (HRM region). Three alleles of this region, P1, P2, and P3, have been identified that contain two, three and four repeats of the hexanucleotide, respectively. H-ras possesses a minisatellite DNA of the variable tandem repeat (VTR), which is located 1000 bp downstream of the gene displaying linkage disequilibrium with HRM," wrote E.N. Papadakis and colleagues, University of Crete, School of Medicine.
"The purpose of this study was to estimate the frequency of P1, P2 and P3 in the normal population and in patients with breast cancer. We studied 56 biopsy specimens from patients with breast cancer, 61 normal blood samples, and 30 pairs of normal and tumoral breast tissues for VTR analysis," the researchers wrote.
"There was a difference in the ...
- P1 homozygosity may be a potential risk factor in breast carcinogenesis.
- Newspaper article from: Cancer Weekly February 3, 2004 700+ words
...between normal and breast cancer samples. The frequency...high in women with breast cancer compared to healthy...potential risk factor in breast carcinogenesis. In VTR analysis...regions in human breast cancer. Int J Biol Marker...
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...pathways towards breast cancer. "Distinct parallel...cytogenetic pathways in breast carcinogenesis could be identified...the pathogenesis of breast cancer," said E. Korsching...imbalances of 206 invasive breast cancer cases were characterized...
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