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Beta[subscript]3 integrin expression can lead to increased tumor cell aggressiveness.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Study suggest that increased expression of the alpha[subscript]vbeta[subscript]3 integrin during breast cancer progression can result in increased tumor cell aggressiveness.
"Osteopontin (OPN) is a secreted phosphoprotein that has been associated with malignancy of breast and other cancers. OPN binds to several cell surface integrins including alpha[subscript]vbeta[subscript]3, alpha[subscript]vbeta(5), and alpha[subscript]vbeta[subscript]1," investigators in Canada report.
"Although the relative contribution of these integrins to breast cancer cell malignancy is uncertain, correlative studies suggest that alpha[subscript]vbeta[subscript]3 may be particularly associated with increased tumor aggressiveness," wrote K.A. Furger and colleagues, London Health Science Center, Department of Pathology.
"Previously, we reported that tumorigenic, nonmetastatic 21NT mammary carcinoma cells respond to OPN through alpha[subscript]vbeta[subscript]5 and alpha[subscript]vbeta[subscript]1 but not alpha[subscript]vbeta[subscript]3. Here, we determined that 21NT cells lack beta[subscript]3 expression, and we asked whether expression Of alpha[subscript]vbeta[subscript]3 could enhance the ability of breast cancer cells to respond to the malignancy-promoting effects of OPN both in vitro and in vivo," the researchers wrote.
"21NT cells stably transfected with beta[subscript]3 showed significantly increased adhesion, migration, and invasion to OPN in vitro compared with vector control. To determine if beta[subscript]3 could also enhance the response of breast epithelial cells to ...
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Source: HighBeam Research, Beta[subscript]3 integrin expression can lead to increased tumor cell...