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CD105/endoglin is a marker for endometrial cancer angiogenesis.

Women's Health Weekly

| February 05, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 FEB 5 - (NewsRx.com & NewsRx.net) -- CD105/endoglin is a marker for endometrial cancer angiogenesis.

"Angiogenesis is a key process in tumor growth and metastasis, and factor-VIII microvascular density has been found to influence prognosis among endometrial carcinoma patients. The CD105/endoglin antibody has been reported to preferentially bind to activated endothelial cells in tissues participating in angiogenesis, and we therefore wanted to compare the prognostic significance of CD105/endoglin to that of factor-VIII," scientists in Norway stated.

"In a population-based endometrial carcinoma study with long (median 11.5 years) and complete patient follow-up, mean intratumor microvascular density (MVD) assessed using CD105/endoglin was investigated and compared with previous data for MVD assessed using factor-VIII. MVD by CD105/endoglin was significantly correlated with MVD by factor-VIII (p=0.001)," reported H.B. Salvesen and colleagues, Haukeland University Hospital, Department of Obstetrics and Gynecology.

"However, tumors within the two groups defined by the upper and lower quartiles for CD105/endoglin-MVD were both significantly more often metastatic (FIGO-stage III/IV, p=0.03), with high tumor cell proliferation by Ki67 (p=0.007) and with reduced survival (p=0.036) as compared with the intermediate groups. In Cox regression ...

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