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Glycated compounds spawn angiogenic induction in cultured endothelial cells.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Glycated compounds spawn angiogenic induction in cultured endothelial cells.
According to a study from Japan, "glycation has been implicated in the endothelial dysfunction that contributes to both diabetes- and aging-associated vascular complications. The aim of the present study was to determine whether Amadori-glycated phosphatidylethanolamine (Amadori-PE), a lipid-linked glycation compound that is formed at an increased rate in hyperglycemic states, affected proliferation, migration and tube formation of cultured human umbilical vein endothelial cells (HUVEC). Amadori-PE at a low concentration of
"Furthermore, stimulation of HUVEC with Amadori-PE resulted in secretion of matrix metalloproteinase 2 (MMP-2), a pivotal enzyme in the initial step of angiogenesis," noted J.H. Oak and colleagues, Tohoku University, Graduate School Life Sciences and Agriculture.
"Our results demonstrated for the first time that Amadori-PE may be an important compound that promotes vascular disease as a result of its angiogenic ...
- Glycated compounds spawn angiogenic induction in cultured endothelial cells.
- Newspaper article from: Heart Disease Weekly February 8, 2004 700+ words
...umbilical vein endothelial cells (HUVEC). Amadori-PE at a...activity on endothelial cells. We also...mediator of Amadori-PE-driven...Letters (Amadori-glycated...umbilical vein endothelial cells. FEBS Lett...
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...FirstCall/ -- IBM today announced Gruppo Amadori, a wholesale distributor of quality food...year. The benefits that drive Gruppo Amadori's migration to Linux and IBM collaboration...and Director of Organization, Gruppo Amadori. "For us, the Linux environment is...
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...both IL-6 and TNF-alpha," wrote M. Amadori and colleagues (see also Interferon...the response to the weaning stress." Amadori and colleagues published their study in...For additional information, contact M. Amadori, Ist Zooprofilatt Sperimentale, Cellular...
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- A post-amadori inhibitor pyridoxamine also inhibits chemical modification of...
- Magazine article from: Life Extension July 1, 2009 700+ words
...studied the reaction of carbonyl compounds glyoxal (GO) and glycolaldehyde (GLA) with pyridoxamine (PM), a potent post-Amadori inhibitor of AGE formation in vitro and of development of renal and retinal pathology in diabetic animals. PM reacted rapidly...
- Genitalia Reconstruction "Reconstitution of Corporal Tissue Using Human...
- Newspaper article from: Gene Therapy Weekly January 11, 1999 700+ words
...composed of corporal smooth muscle and endothelial cells, would be beneficial to these patients...combining corporal smooth muscle with endothelial cells. METHOD: Primary normal human corpus...cavernosal smooth muscle cells and ECV 304 endothelial cells were used in this study. Both ...
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- Magazine article from: BIOWORLD Today Breindl, Anette April 30, 2008 700+ words
...researchers published the claim that endothelial cells lining new blood vessels during tumor...but others defended its merits. Endothelial cells line blood vessels, and when new...such angiogenesis requires new endothelial cells, among other cell types. And research...
