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Estrogen protects cells from certain death after an ischemic stroke.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Estrogen protects cells from certain death after an ischemic stroke.
"Estradiol is a known neurotrophic and neuroprotective factor. Our previous work demonstrated that replacement with physiological concentrations of estradiol protects the cortex against middle cerebral artery occlusion (MCAO)-induced cell death. The cerebral cortex exhibits caspase-dependent programmed cell death (PCD) in many models of focal cerebral ischemia," researchers in the United States report.
"We hypothesized that estradiol attenuates PCD during stroke injury. The current study explored the temporospatial pattern of markers of PCD, their relationship to the evolution of injury, and their modulation by estradiol. Rats were ovariectomized and treated with either estradiol or vehicle. One week later, rats underwent middle cerebral artery occlusion (MCAO), and brains were collected at 1, 4, 8, 16, and 24 hours (hr)," wrote S.W. Rau and colleagues, University of California, Davis, Division of Biological Sciences.
"We assessed the temporospatial evolution of infarction volume, DNA fragmentation, and levels of spectrin cleavage products in ischemic cortex. Estradiol led to a delay and attenuation of injury-mediated DNA fragmentation as early as 8 hr after MCAO. Estradiol also dramatically reduced the level of the 120 kDa ...
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Source: HighBeam Research, Estrogen protects cells from certain death after an ischemic stroke.