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Vertebral bone density improves in women who use estradiol implants for 5 years.
2004 FEB 5 - (NewsRx.com & NewsRx.net) -- Vertebral bone density improves in women who use estradiol implants for 5 years.
According to published research from England, "the aim of this study was to observe whether bone mineral density (BMD) improves over 5 years in older women using estradiol implants. A total of 18 women were selected who had commenced hormone replacement therapy (HRT) around the age of 60 years. The median age was 60.9 years (range 59.7-63.2 years)."
"Each woman had a pretreatment bone scan and then received 6-monthly subcutaneous 50 mg estradiol implants. Twelve untreated women were also selected who had had bone scans at baseline and after 5 years. A comparison of the changes in BMD between treated and untreated women was made using the Wilcoxon rank-sum test," reported A. Vashisht and colleagues, Lister Hospital.
"All changes at the hip and spine were statistically significant improvements from baseline in the estradiol-treated group. After 5 years of treatment, the estradiol-treated group had significantly improved bone mineral densities compared with the untreated group. At the spine, the plasma estradiol concentration is statistically significantly correlated with the 5-year increase in bone density (r=0.717, p=0.004). There was found to be an inverse relationship ...
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Source: HighBeam Research, Vertebral bone density improves in women who use estradiol implants...