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2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant elicited a significant immune response to respiratory syncytial virus infection.
According to a study from the United States, "CpG oligodeoxynucleotides (ODN) were identified that stimulated immunoglobulin production and cell proliferation in cotton rat cells in vitro. Three of these ODN were used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory syncytial virus fusion (F) protein. The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to respiratory syncytial virus."
"Such immunized animals had a marked reduction in the production of infectious virus after a live-virus challenge," reported Gregory A. Prince and collaborators at Virion Systems Inc., the University of California-Los Angeles, and the U.S. Food and Drug Administration. "Animals immunized with the combination of F protein and CpG developed enhanced pulmonary pathology consisting of alveolitis and interstitial pneumonitis after a live-virus challenge. Similar enhanced ...
Source: HighBeam Research, Vaccine elicits immune response against respiratory syncytial virus.