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Vaccine elicits immune response against respiratory syncytial virus.

Vaccine Weekly

| February 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant elicited a significant immune response to respiratory syncytial virus infection.

According to a study from the United States, "CpG oligodeoxynucleotides (ODN) were identified that stimulated immunoglobulin production and cell proliferation in cotton rat cells in vitro. Three of these ODN were used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory syncytial virus fusion (F) protein. The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to respiratory syncytial virus."

"Such immunized animals had a marked reduction in the production of infectious virus after a live-virus challenge," reported Gregory A. Prince and collaborators at Virion Systems Inc., the University of California-Los Angeles, and the U.S. Food and Drug Administration. "Animals immunized with the combination of F protein and CpG developed enhanced pulmonary pathology consisting of alveolitis and interstitial pneumonitis after a live-virus challenge. Similar enhanced ...

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Source: HighBeam Research, Vaccine elicits immune response against respiratory syncytial virus.

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