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B. pertussis toxin induces T-cell responses against melanoma.
2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes.
"The adenylate cyclase (CyaA) of Bordetella pertussis is able to deliver CD8+ T cell epitopes into the cytosol of CD11b+ dendritic cells (DC) following its specific interaction with the alpha(M)beta(2) integrin (CD11b/CD18). This delivery results in intracellular processing and presentation by MHC class I molecules of the CD8+ T cell epitopes inserted into CyaA. Indeed, we previously showed that CyaA toxins carrying a single cytotoxic T lymphocyte (CTL) epitope can induce efficient protective and therapeutic antitumor immunity in mice," researchers in France and Belgium report.
"With a view to elaborating cancer immunotherapy in humans using CyaA, we constructed two recombinant CyaA carrying HLA*0201-restricted melanoma epitopes," stated Gilles Dadaglio at the Institut Pasteur in Paris and collaborators in France and Belgium. "Here we show that these recombinant CyaA induce strong anti-melanoma CTL responses in HLA*0201 transgenic mice, even after a single i.v. immunization without adjuvant. These responses are long lasting, since they were also detected five months after the last injection. Finally, human DC treated with the recombinant CyaA were shown to ...
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- B. pertussis toxin induces T-cell responses against melanoma.
- Newspaper article from: Health & Medicine Week February 2, 2004 700+ words
...tumoral epitopes inserted into CyaA are efficiently processed...observations suggest that CyaA is capable of activating antitumoral...highlight the potential of CyaA for use in cancer immunotherapy...associates published their study in International Immunology (Recombinant adenylate ...
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Source: HighBeam Research, B. pertussis toxin induces T-cell responses against melanoma.