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Leishmania donovani with BCG protects against leishmaniasis.
2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Autoclaved Leishmania donovani with BCG has prophylactic potential against experimental visceral leishmaniasis.
According to a study from India, "The prophylactic efficacy of autoclaved Leishmania donovani (ALD) and autoclaved L. major (ALM) - a heterologous vaccine developed against cutaneous leishmaniasis (used as a reference vaccine), along with BCG - was evaluated against L. donovani in hamsters (Mesocricetus auratus)."
"Animals were immunized with triple doses (21 days apart) of either ALD or ALM (1.0 mg) with or without BCG (0.1 mg) and challenged 21 days later with 1x10[superscript]6 L. donovani amastigotes intracardially," stated J. K. Srivastava and collaborators at the Central Drug Research Institute and the Sanjay Gandhi Post-Graduate Institute of Medical Sciences in India. "Animals immunized with ALM+BCG and ALD+BCG yielded 94.3% and 86.1% parasite inhibition respectively in comparison to the BCG only and unvaccinated controls. Fifty and 33.3% of the vaccinated animals (ALM+BCG and ALD+BCG respectively) were completely devoid of parasites when tested on day 45 post-challenge (p.c.) and survived till the experiment was terminated."
"The mean survival of ALM+BCG and ALD+BCG groups (animals harboring parasites) was longest (168 and 139 days respectively)," ...
- BCG vaccination in south African HIV-exposed infants--risks and...
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- Newspaper article from: Vaccine Weekly Boyles, Salynn May 17, 1999 700+ words
...785-790). Bacillus Calmette-Guerin (BCG) vaccine has been used in humans for more...become the most commonly used method of BCG administration and is believed to minimize...vaccinations also minimize the cfu dose of BCG required to induce positive PPD responses...
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- Newspaper article from: Vaccine Weekly June 22, 1998 700+ words
...stimulation. Bacillus Calmette-Guerin (BCG), the only vaccine available for the prevention...percent to 80 percent in field trials. "BCG should be improved, e.g., by genetic...dependency between M. tuberculosis and BCG, confirmed through murine studies, occurs...
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...risk of reactivation from focal reactions after BCG vaccination." The cost-effectiveness of the BCG program has been shown to be inversely proportional...Consequently, critical evaluation of the BCG vaccination programs is underway. General BCG...
- Surgical management of BCG vaccine-induced regional axillary lymphadenitis in...
- Magazine article from: South African Journal of Surgery Juzi, J.T. Sidler, D. Moore, S.W. May 1, 2008 700+ words
...current vaccine, bacille Calmette-Guerin (BCG), it has been the subject of considerable...rate arising from the use of the current BCG strain is estimated at approximately 36...reason for urgent surgical consultation is BCG-related local reactions and a severe ipsilateral...
- BCG Vaccine Dangerous for Children with Primary Immunodeficiency.
- Newspaper article from: TB & Outbreaks Week June 13, 2000 700+ words
...com) -- Bacillus Calmette-Guerin (BCG) vaccine is contraindicated in children...schedule for children in Brazil includes BCG and some live virus vaccines," said E...Brazil. "Immunization schedule begins with BCG in the first month of life, oral polio...
- Different Protective Effects of BCG Vaccine Evaluated.
- Newspaper article from: TB & Outbreaks Week August 8, 2000 700+ words
...com) -- Bacillus Calmette-Guerin (BCG) vaccine against pulmonary tuberculosis...children from Malawi. "Glaxo (now Evans) BCG vaccine has consistently been shown to provide...populations may account for this variation in BCG efficacy. Parallel studies, using similar...
- BCG Vaccine Dangerous for Children with Primary Immunodeficiency.(Brief...
- Newspaper article from: Vaccine Weekly June 14, 2000 700+ words
...com) -- Bacillus Calmette-Guerin (BCG) vaccine is contraindicated in children...schedule for children in Brazil includes BCG and some live virus vaccines," said E...Brazil. "Immunization schedule begins with BCG in the first month of life, oral polio...