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Hepatitis C glycoprotein expression leads to cryptic intron excision.
2004 FEB 4 - (NewsRx.com & NewsRx.net) -- Expression of unmodified hepatitis C virus envelope glycoprotein-coding sequences leads to cryptic intron excision and cell surface expression of E1/E2 heterodimers comprising full-length and partially deleted E1.
According to published research from the United States, "Hepatitis C virus (HCV) is a positive-strand RNA virus that replicates exclusively in the cytoplasm of infected cells. The viral envelope glycoproteins, E1 and E2, appear to be retained in the endoplasmic reticulum, where viral budding is thought to occur. Surprisingly, we found that the expression system used to generate HCV envelope glycoproteins influences their subcellular localization and processing."
"These findings have important implications for optimizing novel HCV fusion and entry assays as well as for budding and virus particle formation," said Julie Dumonceaux and collaborators at Albert Einstein College of Medicine, Progenics Pharmaceuticals, Inc., and the Nebraska ...
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Source: HighBeam Research, Hepatitis C glycoprotein expression leads to cryptic intron excision.