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DNA vaccine elicits strong immune response against malaria sporozoites.
2004 FEB 4 - (NewsRx.com & NewsRx.net) -- A novel construct containing functional domains of Plasmodium cynomolgi circumsporozoite (CS) and thrombospondin-related adhesive protein (TRAP) elicited a strong immune response in monkeys.
According to a study from India, "We report the efficacy of a bimodal immunization regimen that involved priming with naked DNA (multiple doses) followed by a booster with recombinant protein in rhesus monkeys with a chimeric construct containing the N-terminus of thrombospondin-related adhesive protein and the C-terminus of circumsporozoite protein of Plasmodium cynomolgi."
"The vaccinated animals developed high titer antibodies against the chimeric antigen, the two components of the hybrid and the native proteins of sporozoites," reported Devesh Bhardwaj and collaborators at the International Centre for Genetic Engineering and Biotechnology and the Central Drug Research Institute in India. "The peripheral blood mononuclear cells isolated from the vaccinated animals had significant in vitro T cell proliferation activity when stimulated with the recombinant chimeric protein. Furthermore, following challenge with 1000 P. ...
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Source: HighBeam Research, DNA vaccine elicits strong immune response against malaria...